by Brian T. Lynch, MSW
(If you are returning to this site just skip down to today's data table and comments below)
Welcome to the Daily Pandemic Diary for October 2020. The daily statistical tables below are divided into four parts, the U.S. daily global share of new cases in the prior 24 hour period, the U.S. daily global share of COVID-19 related deaths in the same 24 hour period, a commentary section, and a graphic of the raw data table from which the raw data is reported. The data comes from the international Worldometer.info website. The main purpose here is to provide a daily snapshot of how the U.S. is doing relative to the world as a whole. The twenty-four-hour lookback is based on Grenich Mean-time. The Total Tests/U.S. The population is the ratio of all COVID-19 tests given relative to the population of only one test was given per person.
This blog continues the daily collection of data begun in the Daily Update blog mentions below and the Daily Pandemic Diary for the past months.
Comments: It's the last day of the week and the last day of a scary month. Fittingly, it is Holloween, the first day of the new year for any ancient Celts out there. Happy Samhaim! For the rest of us, let's hope this is the start of a new commitment to change our behaviors so we can slow the spread of this awful virus.
On the other hand, Eli Lilly’s experimental anti-viral drug proved completely ineffective in a level 3 clinical trial for patients hospitalized with COVID-19. Two days later the Trump administration struck a deal to buy up to 950,000 doses of this useless drug at a cost of $1,247 per dose. The doses would be given free of charge to people with mild symptoms, who do not require hospitalization, in the hope that it might help them recover more quickly. That deal equals a total cost potential of $1.18 billion dollars in sales once the FDA issues an emergency use authorization.
The money spent on this proven ineffective therapeutic is enough to purchase 1.87 billion N95 cone masks for free in a targeted distribution plan where hotspots justify mask mandates. That number of masks is at the retail price of 63¢ each. The President has the power to invoke the Defense Production Act to purchase more than double that number of the same cost. This is another glaring example of why national leadership matters.
"More than 350,000 people in England have taken an antibody test as part of the REACT-2 study... at the end of June and the beginning of July, about 60 in 1,000 people had detectable antibodies... in September, only 44 per 1,000 people were positive [suggesting that] the number of people with antibodies fell by more than a quarter between summer and autumn."
While we can't make too much of this finding right now, it should be a factor considering a greater emphasis on prevention measures as we approach the winter months.
Comments: The highest one-day total of new cases to date was 78,941on July 25th (A correction from yesterday). Today the new case total of 71,687 approaches that all-time high. This number will decline over the next few days as more states decline to report their statistics over the weekend, but it will rebound and it will likely set a new record high before next week is out. How many days did it take for newly reported infections to double in getting to this figure? On September 12th the 7-day running average was 35,584, nearly half of today's new cases, exactly six weeks ago (35 days). So what are the projections between now and the new year?
Comments: The U.S. total number of newly reported COVID-19 cases in the past 24 hours has exceeded new cases in India for the first time in over a month. We are #1 in the world again with over 66 thousand new reports, except this time the building wave is not due to very high numbers in very few places. Twenty-six states (including New York) had more than 1,000 new reports and another 12 states (including New Jersey) had between 587 and 980 new cases. Resources need to treat the sick are spread out across the whole country for the first time. Scores of states and hundreds of local governments will have to grapple with how to strengthen restrictions to bring the numbers down, all without the benefit of a national policy or nationally managed resources. It's every state for itself. The last time we had numbers this high was on July 31, 2020. The highest one-day total of new cases to date was 78,941on July 25th. We are close to that already.
Comments: The U.S. is still one of the hottest hotspots for COVID-19 in the world. No news there! New infections in the past 24 hours nearly totaled 60 thousand, and that is with all states reporting on new cases this time. COVID testing is consistently around a million tests a day, which is welcome news but still about 2 million per day short of what we need. And testing should be free or at low cost to all if we had a national emergency policy for this disease. I was at a test facility recently and noticed that people with insurance had to pay a $100 co-pay plus $100 uncovered cost for a rapid COVID test. We don't have a national strategy, but the current administration is formulating one now.
Donald Trump and members of his Cabinet are maneuvering to pursue a "Herd Immunity" strategy. This would mean doing nothing to prevent anyone from getting ill, or perhaps encouraging infections such as the President's mass rallies are doing already. It is a survival of the fittest idea that letting the virus run through the population will "cull the herd" of less healthy people while conveying immunity on enough of the survivors to protect everyone else from becoming exposed. If President Trump wins a second term, this is the pandemic policy we can expect from our government. So, what would that look like?
On 9/28/2020 a new study led by Stanford School of Medicine investigators reported that 9% of people nationwide have been infected with the COVID-19 virus. This was based on thousands of positive anti-bodies tests of blood samples taken from dialysis patients all around the country. They estimate that 60%-70% of the population must have antibodies to the coronavirus before the spread of COVID-19 begins to decline. This suggests another 50% to 60% of the population still has to get infected before herd immunity can start having an effect. Also, it reveals that about 28 million people have already gotten the virus, compared with about 8 million new cases officially reported. Do the math and that means 152 to182 million more people would need to catch the virus before herd immunity would start to kick in.
Let's make the very optimistic assumption that any amount of COVID anti-bodies conveys perfect and lasting immunity, and that only 175 million more people have to get infected for herd immunity to end the spread of the disease. Under these circumstances, the number of deaths it would take to achieve herd immunity would be 175,000,000 multiplied by the fatality rate. There are many ways to calculate the fatality rate and there is no perfect answer so far in this pandemic. Based strictly on reported new cases and deaths from COVID-19 in this country, the mortality rate would appear to be 2.7%. But, if over 28 million people have already been infected, 3.7 times more than new cases being reported every day, than the actual mortality rate must be much lower (and are the reported number of death accurate?)
Comments: Again, data is missing from several states. No death data were reported in Alabama, South Dakota, or Utah. No new case data or deaths were reported in Missouri, and no new case data were reported in Kansas. I am still waiting for word from John's Hopkins University regarding discrepancies in the testing positivity they reported last month. We reached a milestone of sorts. As of today, the total number of COVID-19 tests given to date is equal to one-third of the U.S. population.
Although they are not close fitting, blue, disposable masks are fluid resistant and provide some protection against larger respiratory droplets from coughs and sneezes. Primarily, they prevent the wearer from spreading infectious droplets to others. They are best used in settings where aerosol buildup isn’t an issue, such as outdoors.
To be clear, the only reason the CDC recommended cloth masks is because procedural masks and N95 masks were in such short supply. It was more critical that healthcare professionals have them, otherwise high infection rates among them would incapacitate our hospitals. We are now 212 days into this national crisis. We should have an adequate supply of N95 masks by now, but we don’t. So buy them in modest quantities (no hoarding!), reuse them, put them in a rice cooker occasionally to sanitize them, but only use them when the situation requires that level of protection.
NATIONAL HEALTH EMERGENCY
NATIONAL HEALTH EMERGENCY
DAY 206 - OCTOBER 6, 2020
COMMENTS: Our President is out of the hospital and acting like conquering the COVID hero if only he would wear a mask. Everyone at his stage of the illness is still shedding virus. If you, or anyone you know, tested positive for COVID-19 pleases remember that you can still infect others for weeks after you have recovered from the symptoms.
Regarding U.S. positivity rates and the John’s Hopkins data anomaly, , I received a response to my inquiry from Mary Conway Vaughn, a Senior Program Coordinator. She apparently misunderstood the scope of my inquiry and offered an explanation for why there might have been a one-day anomaly in the data. (Texas apparently withdrew 300,000 tests due to some error they had made.) I have sent her a fuller account of the data anomaly and hope to hear back from her soon. Here below is a partial text of my letter back to her and a partial screenshot of the data table I send her.
"To illustrate my confusion, I am attaching a table comparing the positivity rates published on the two different pages in the John's Hopkins Coronavirus Resource Center Website. The International Comparison page data is listed in the second column. Between the 1st of September and the 16th, it is completely different from the data published on your State-by-State Comparison page data listed in the third column. On 17 September, a transition began to bring the numbers in sync, and from 24 September on they are the same values. That is how it appears. Where there two competing methods for calculating positivity rates prior to the 16th? What changed, and why?"
NATIONAL HEALTH EMERGENCY
DAY 205 - OCTOBER 5, 2020
NATIONAL HEALTH EMERGENCY
DAY 204 - OCTOBER 4, 2020
Day 203 - October 3, 2020
NATIONAL HEALTH EMERGENCY
Day 202 - October 2, 2020
Comments: Today is the second day of October and the 202nd day of the U.S. National Health Emergency. Today we learned that among the 4,739 who tested positive for the COVID-19 virus in the past 24 hours are the President of the United States, Donald Trump, First Lady Melania Trump, and top aid to the President, Hope Hicks. Then we learned that both Ms. Hicks and the President is exhibiting minor symptoms. In the case of the President, he is fatigued, has a sore throat and a raspy sounding voice. Later this evening he spiked a fever and is now admitted to Walter Reid Hospital. We wish them all well, and a speedy recovery, of course. But what does the term “mild symptoms” mean and what does it say about prognosis and recovery from the virus. What questions should we be asking? Do all COVID-19 virus cases usually start with "mild" symptoms? And, what should we look for to assess the risk Donald Trump, and others, face given the early symptoms they exhibit?
A friend, who is a scientist in a medical lab and another friend, who is a medical doctor, offered the following insight into that question:
Do all COVID-19 virus cases usually start with "mild" symptoms? What should we look for to assess the risks that Donald Trump faces given what we know so far?
COVID-19 cases can start out with mild symptoms. But here’s the thing to look for, the symptoms tend to appear in a particular order. Which symptoms appear and in what order will tell a lot about the progression timeline and the risk of progression to more severe reactions.
In the case of President Trump, I would be curious to know his early blood pressure readings. This can tell if there is whole-body inflammation, which can signal that he is at a higher risk for a cytokine storm. This is a severe and life-threatening complication.
We know so little about President Trump’s actual health it’s so hard to know how to assess his risk factors. Assessing anyone’s prognosis has long been the tricky part with COVID-19 because it was incorrectly categorized as a respiratory disease in the beginning. People often think of it as producing a cough, a sore throat, and cold symptoms in general. It may, but the way it works is that the virus binds to one particular type of channel, or doorway, on some cell walls, and that doorway lets it into the cell where it wreaks havoc. In the lung, it can stop the body from clearing fluid.
But that same type of cell wall channel also exists in the intestine, spleen, blood vessels, heart, and brain. So, it can eventually infect cells in other areas. That’s when the infection can cause excessive inflammation and worsens the effect it has on the lungs. Initially, you might see an increase in blood pressure. If the infection isn’t brought under control after that, the vascular tissues in other affected places will begin to leak resulting in a sudden drop in blood pressure. If a patient has a history of metabolic syndrome or hypertension caused by atherosclerosis, these could actually add a significant risk of hemorrhagic stroke. For too long so much about this virus has been downplayed by comparing it to a “bad cold.”
The anesthesiologist added: I would also ask if they are monitoring his oxygen saturation. Asymptomatic hypoxia is a common symptom exhibited prior to hospital admission. [This is a condition where the blood oxygen level drops to dangerously low levels, usually below 90% saturation, without producing the expected symptoms, such as shortness of breath, headaches, rapid heart-beats, etc.]
We know less about the health fitness of this President than is usual, so it is anyone’s guess what we should expect next.
(PS: I am not shouting. Google BlogSpot, who hosts this site, recently completely updated this application and created a mess of formatting glitches that I have not yet been able to work around.)
Addendum: Vickie Cordero, who provided much of the information for this post, is a medical research facility on therapeutics for the treatment of metabolic syndrome and inflammatory conditions. She recently published an article on therapeutic approaches to sepsis, diabetes and has also published articles on how these approaches apply to COVID-19 applications.
A friend, who is a scientist in a medical lab and another friend, who is a medical doctor, offered the following insight into that question:
Do all COVID-19 virus cases usually start with "mild" symptoms? What should we look for to assess the risks that Donald Trump faces given what we know so far?
COVID-19 cases can start out with mild symptoms. But here’s the thing to look for, the symptoms tend to appear in a particular order. Which symptoms appear and in what order will tell a lot about the progression timeline and the risk of progression to more severe reactions.
In the case of President Trump, I would be curious to know his early blood pressure readings. This can tell if there is whole-body inflammation, which can signal that he is at a higher risk for a cytokine storm. This is a severe and life-threatening complication.
We know so little about President Trump’s actual health it’s so hard to know how to assess his risk factors. Assessing anyone’s prognosis has long been the tricky part with COVID-19 because it was incorrectly categorized as a respiratory disease in the beginning. People often think of it as producing a cough, a sore throat, and cold symptoms in general. It may, but the way it works is that the virus binds to one particular type of channel, or doorway, on some cell walls, and that doorway lets it into the cell where it wreaks havoc. In the lung, it can stop the body from clearing fluid.
But that same type of cell wall channel also exists in the intestine, spleen, blood vessels, heart, and brain. So, it can eventually infect cells in other areas. That’s when the infection can cause excessive inflammation and worsens the effect it has on the lungs. Initially, you might see an increase in blood pressure. If the infection isn’t brought under control after that, the vascular tissues in other affected places will begin to leak resulting in a sudden drop in blood pressure. If a patient has a history of metabolic syndrome or hypertension caused by atherosclerosis, these could actually add a significant risk of hemorrhagic stroke. For too long so much about this virus has been downplayed by comparing it to a “bad cold.”
The anesthesiologist added: I would also ask if they are monitoring his oxygen saturation. Asymptomatic hypoxia is a common symptom exhibited prior to hospital admission. [This is a condition where the blood oxygen level drops to dangerously low levels, usually below 90% saturation, without producing the expected symptoms, such as shortness of breath, headaches, rapid heart-beats, etc.]
We know less about the health fitness of this President than is usual, so it is anyone’s guess what we should expect next.
This comment has been removed by a blog administrator.
ReplyDelete